Samitol Drug Interactions

Secnidazole tablets should not be associated with disulfiram because there is the risk of onset of acute confusional and psychotic states.
Intake of alcohol is discouraged along with Secnidazole, because it can cause abdominal cramps, facial flushing, vomiting, and tachycardia.
It potentiates the anticoagulant effect of warfarin, so concurrent administration should be done under strict medical supervision. The prothrombin time must be carefully monitored and dosage adjustments should be made whenever necessary.
Lithium: Lithium plasma levels may be increased.
Cyclosporine: Risk of increased serum levels of cyclosporine. Cyclosporine level and serum creatinine should be tightly controlled where simultaneous administration is necessary.
5-Fluorouracil: Decreased clearance of 5-fluorouracil, which yields an increasing the toxicity of 5-fluorouracil.
The drug is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide).
In combination with amoxicillin, activity of Helicobacter pylori is increased (Amoxicillin suppresses development of resistance).