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Warfarin: Co-administration of rosuvastatin to patients on stable warfarin therapy resulted in clinically significant rises in INR (>4, baseline 2-3).
Coumarin: In patients taking coumarin anticoagulants and rosuvastatin concomitantly, INR should be determined before starting rosuvastatin and frequently enough during early therapy to ensure that no significant alteration of INR occurs.
Antacid: The antacid should be taken at least 2 hrs after rosuvastatin administration.
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