Rovista Dosage/Direction for Use

The patient should be placed on a standard cholesterol-lowering diet before receiving rosuvastatin and should continue on this diet during treatment with rosuvastatin. Rosuvastatin can be administered as a single dose at any time of the day, with or without food.
Homozygous Familial Hypercholesterolemia: Recommended Starting Dose: 20 mg once daily in patients with homozygous familial hypercholesterolemia. Maximum Recommended Dose: 40 mg daily. Rovista should be used in these patients as an adjunct to other lipid-lowering treatments.
The following guidelines may be used to establish treatments goals: See table.

Click on icon to see table/diagram/image

Mixed Dyslipidemia (Fredrickson Type IIa and IIb): Dose Range: 5-40 mg once daily. Therapy with rosuvastatin should be individualized according to goal of therapy and response. Usual Recommended Dose: 10 mg once daily. Initiation of therapy with 5 mg once daily may be considered for patients requiring less aggressive LDL-C reductions or who have predisposing factors for myopathy.
Patients with Marked Hypercholesterolemia (LDL-C >190 mg/dL) and Aggressive Lipid Targets: Starting Dose: 20 mg. After initiation and/or upon titration of Rovista, lipid levels should be analyzed within 2-4 weeks and dosage adjusted accordingly. The 40-mg dose of Rovista is reserved only for those patients who have not achieved its LDL-C goal utilizing the 20-mg dose of Rovista once daily.
Elevated Serum Triglyceride Levels (Hypertriglyceridemia/Frederickson Type IV): Dose Range: 5-40 mg once daily. Usual Starting Dose: 10 mg/day with adjustments based on lipid levels, monitored once daily 2-4 weeks until desired level is achieved.