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Where renal function is impaired through disease or old age, the frequency, but not the amount of each dose should be reduced according to the degree of impairment. Gentamicin is excreted by simple glomerular filtration, and dosage frequency may be predicted by assessing creatinine clearance rates or blood urea and reducing the frequency accordingly.
It is also advisable to check serum levels to confirm that peak (one hour) levels do not exceed 10 mcg/mL and that trough levels (before next injection) do not exceed 2 mcg/mL.
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