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Intentional overdosing with meropenem is unlikely, although accidental overdosing might occur particularly in patients with reduced renal function.
The largest dose of meropenem administered in clinical studies involving patients with normal renal function has been 2 g IV given every 8 hours in adults (40 mg/kg body weight every 8 hours in children). No adverse pharmacological effects or increased safety risks were observed at this dosage.
In mice and rats, large IV doses of meropenem (2200 to 4000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities.
No information is available for the treatment of meropenem overdosage. In the event of an overdose, discontinue the drug and give general supportive treatment until renal elimination takes place. Although meropenem is hemodialyzable, there is no information on the usefulness of hemodialysis to treat overdosage.
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