RiteMED Meropenem Trihydrate Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Meropenem trihydrate

Indications/Uses

Skin & skin structure, intra-abdominal, lower resp tract & gynecological infections; bacterial meningitis; complicated UTI; septicemia. Empiric treatment of patients w/ febrile neutropenia as monotherapy or combination therapy w/ other antimicrobial drugs.

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Dosage/Direction for Use

IV Administer bolus inj 5-20 mL over approx 3-5 min or infusion over approx 15-30 min. Adult 500 mg to 1 g every 8 hr. Skin & skin structure infections, gynecological infections & complicated UTI 500 mg every 8 hr. Intra-abdominal infections, septicemia & febrile episodes in neutropenic patients 1 g every 8 hr. Bacterial meningitis 2 g every 8 hr. Lower resp tract infections: community-acquired pneumonia (CAP) 500 mg every 8 hr, healthcare-associated pneumonia 1 g every 8 hr, cystic fibrosis up to 2 g every 8 hr. Childn >50 kg Adult dose for 7-14 days. Childn 3 mth to 12 yr weighing 50 kg 10-40 mg/kg every 8 hr. Complicated UTI 10 mg/kg/dose every 8 hr. Complicated intra-abdominal infection & febrile episodes in neutropenic patient 20 mg/kg/dose every 8 hr. Skin & skin structure infections & CAP 10-20 mg/kg/dose every 8 hr. Cystic fibrosis & meningitis 40 mg/kg/dose every 8 hr. Adult Renal impairment CrCl 26-50 mL/min Usual dose every 12 hr, 10-25 mL/min ½ usual dose every 12 hr, <10 mL/min ½ usual dose every 24 hr.

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Overdosage

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Contraindications

Hypersensitivity to meropenem, drugs in the same class or other β-lactams.

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Special Precautions

Hypersensitivity; anaphylactic reactions. Seizure & other CNS experience. Clostridium difficile-associated diarrhea; risk of development of drug-resistant bacteria; overgrowth of non-susceptible organisms. Patients w/ restricted Na diet. Cross-allergenicity among β-lactams including penicillins, cephalosporins or other β-lactams. Concomitant use w/ valproic acid. +ve direct or indirect Coombs' test. Renal & hepatic impairment. Avoid performing tasks requiring complete mental alertness eg, driving & operating machinery. Pregnancy & lactation. Childn <3 mth. Elderly.

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Adverse Reactions

GI effects (diarrhea, nausea, vomiting, constipation), local reactions (pain, edema & inflammation at inj site, phlebitis/thrombophlebitis), headache, anemia, rash, pruritus, sepsis, apnea, shock, glossitis, oral candidiasis & thrombocytosis. Childn: Rash mostly diaper area moniliasis, oral moniliasis & glossitis.

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Drug Interactions

Synergistic antibacterial effects w/ aminoglycosides. May augment anticoagulant effect of warfarin. Increased plasma conc w/ probenecid. Reduction in acid conc of valproic acid.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view RiteMED Meropenem Trihydrate detailed prescribing information

Storage

View RiteMED Meropenem Trihydrate storage conditions for details to ensure optimal shelf-life.

Description

View RiteMED Meropenem Trihydrate description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Other Beta-Lactams

ATC Classification

J01DH02 - meropenem ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

RiteMED Meropenem trihydrate powd for inj 1 g

Packing/Price

1's (P1,600/vial)

Form

RiteMED Meropenem trihydrate powd for inj 500 mg

Packing/Price

1's (P950/vial)

RiteMED Meropenem Trihydrate

meropenem

Manufacturer:

RiteMED

Distributor:

RiteMED