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The use of Colchicine is contraindicated in pregnancy.
Colchicine should not be used in patients undergoing hemodialysis since it cannot be removed by dialysis or exchange transfusion.
Colchicine should not be used in patients with severe renal impairment (creatinine clearance less than 10 mL/minute).
Colchicine is contraindicated in patients with renal or hepatic impairment who are taking a P-glycoprotein or a strong CYP3A4 inhibitor.
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