RiteMED Colchicine Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Colchicine

Indications/Uses

Acute gout & for short term prophylaxis during initial therapy w/ allopurinol & uricosuric drugs.

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Dosage/Direction for Use

Adult Gout Initially 1 mg followed by 500 mcg every 2-3 hr until pain is relieved or vomiting or diarrhea occurs. Max: 6 mg. Should not be repeated w/in 3 days. Concomitant use w/ allopurinol or uricosuric drugs 500 mcg bid-tid.

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Overdosage

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Administration

Should be taken with food.

Contraindications

Patients undergoing hemodialysis. Severe renal impairment (CrCl <10 mL/min). Patients w/ renal/hepatic impairment receiving P-gp or strong CYP3A4 inhibitor. Pregnancy.

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Special Precautions

Avoid in patients w/ blood disorder. Cardiac, hepatic, GI disease. Debilitated patients. Lactation. Elderly. Not recommended in childn.

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Use In Pregnancy & Lactation

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Adverse Reactions

Abdominal pain, nausea, vomiting, diarrhea.

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Drug Interactions

Concurrent use w/ CYP3A4 or P-gp inhibitors (eg, macrolides (clarithromycin & erythromycin), ciclosporin, ketoconazole, itraconazole, voriconazole, HIV PIs, Ca-channel blockers (verapamil, diltiazem) & disulfiram. Possibility of elevated serum colchicine conc w/ azithromycin. Contraindicated in patients w/ renal or hepatic impairment who are taking a P-gp inhibitor (eg, ciclosporin, verapamil or quinidine) or a strong CYP3A4 inhibitor (eg, ritonavir, atazanavir, indinavir, clarithromycin, telithromycin, itraconazole or ketoconazole).

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Storage

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Description

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Action

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MIMS Class

Hyperuricemia & Gout Preparations

ATC Classification

M04AC01 - colchicine ; Belongs to the class of preparations with no effect on uric acid metabolism. Used in the treatment of gout.

Regulatory Classification

Presentation/Packing

Form

RiteMED Colchicine tab 500 mcg

Packing/Price

100's (P435/box, P4.35/tab)

RiteMED Colchicine

colchicine

Manufacturer:

XL Lab

Distributor:

RiteMED