RiteMED Ciprofloxacin Drug Interactions

Concurrent administration with Theophylline may lead to elevated serum concentrations of Theophylline and prolongation of its elimination half-life. This may result in increased risk of theophylline-related adverse reactions. If concomitant use is necessary, monitor serum levels of theophylline and adjust dosage appropriately.
Ciprofloxacin interferes with caffeine's metabolism leading to reduced clearance and prolongation of its serum half-life.
Altered Phenytoin serum levels (increased or decreased) have been reported in patients given Ciprofloxacin.
Concomitant administration of Ciprofloxacin with Cyclosporine has resulted in transient elevations in serum creatinine.
Ciprofloxacin enhances the effects of oral anticoagulant warfarin or its derivatives. When these products are administered simultaneously, closely monitor prothrombin time or other suitable coagulation tests.
Probenecid interferes with renal tubular secretion of Ciprofloxacin and produces an increase in Ciprofloxacin level in the serum.