RiteMED Ciprofloxacin Dosage/Direction for Use

To be administered orally. (See Table 4.)

Click on icon to see table/diagram/image

Duration of Therapy: Usual duration of treatment is 7 to 14 days; however, for severe and complicated infections more prolonged therapy may be required. Generally, Ciprofloxacin is continued for at least 2 days after the signs and symptoms of infection have disappeared, except for inhalational anthrax (post-exposure).
Patient Information: Ciprofloxacin may or may not be taken with meals. However, if taken on an empty stomach, the drug is absorbed more rapidly.
Do not take Ciprofloxacin with dairy products (like milk or yogurt) or calcium-fortified juices alone since absorption of ciprofloxacin may be significantly reduced; however ciprofloxacin may be taken with a meal that contain these products.
Drink fluids liberally.
Administer Ciprofloxacin at least 2 hours before or 6 hours after magnesium/aluminum antacids or sucralfate, didanosine chewable/buffered tablets or pediatric powder for oral solution or other products containing calcium, iron or zinc.
Patients started on Ciprofloxacin I.V. may be switched to Oral Ciprofloxacin when clinically indicated at the discretion of the physician (see Table 5.)

Click on icon to see table/diagram/image

Impaired Renal Function: Dosage modification is recommended particularly for patients with renal dysfunction. The following table provides dosage guidelines for use in patients with renal impairment; however, monitoring of serum drug levels provides the most reliable basis for dosage adjustment: See Table 6.

Click on icon to see table/diagram/image

When the only serum creatinine concentration is known, the following formula may be used to estimate creatinine clearance. (See equation.)

Click on icon to see table/diagram/image

Serum creatinine should represent a steady state of renal function.
In patients with severe infections and severe renal impairment, a unit dose of 750 mg may be administered at the intervals noted previously; however carefully monitor patients and periodically measure Ciprofloxacin's serum concentration. Peak concentrations (1 to 2 hours after dosing) ranges from 2 to 4 μg/mL.
For patients with changing renal function or for patients with renal impairment and hepatic insufficiency, measurement of serum concentrations of ciprofloxacin will provide additional guidance for adjusting dosage.