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16 mg: There are no proven cases of hazardous interactions. No in-vivo interaction studies have been performed. Based on in-vitro data no in-vivo inhibition on Cytochrome P450 enzymes is expected.
Although an antagonism between Betahistine and antihistamines could be expected on a theoretical basis, no such interactions have been reported.
There is a case report of an interaction with ethanol and a compound containing pyrimethamine with dapsone and another of potentiation of Betahistine with salbutamol.
In vitro data indicate an inhibition of Betahistine metabolism by drugs that inhibit monoamine oxidase (MAO) including MAO subtype B (e.g. selegiline). Caution is recommended when using Betahistine and MAO inhibitors (including MAO-B selective) concomitantly.
Betahistine is a histamine analogue, concurrent administration of H1 antagonists may cause a mutual attenuation of effect of the active agents.
24 mg: An antagonist between Betahistine dihydrochloride and antihistamine could be expected on a theoretical basis. However, no such interactions have been reported.
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