Hypersensitivity: Bisphosphonates may rarely cause hypersensitivity reactions such as angioedema, urticarial, and pruritus. A possibly drug-related rash has also been reported in a patient receiving Alendronate. Other cutaneous reported with Alendronate include urticarial, erythematous papules and petechiae, gyrate erythema, and drug-induced lichen planus; licensed product information states that Stevens-Johnson syndrome has been reported.