Rhinol/Rhinol Plus

Rhinol: Syrup: Each 5 mL (1 teaspoonful) contains Salbutamol (as sulfate) 2 mg.
Rhinol Plus: Cap: Each capsule contains: Guaifenesin 100 mg, salbutamol (as sulfate) 2 mg. Syrup: Each 5 mL (1 teaspoonful) contains: Guaifenesin 50 mg, salbutamol (as sulfate) 1 mg.

Rhinol: Salbutamol is a β-adrenergic stimulant which has a highly selective action on the β₂-receptors in bronchial smooth muscle and, in therapeutic dosage, little or no action on cardiac muscles.
Rhinol Plus: Guaifenesin posseses mucolytic properties, Mucolytics are agents that alter the structure of mucus to decrease its viscosity thereby facilitating its removal by ciliary action or expectoration. Although mucolytics have been shown to affect sputum viscosity and structure, and patients have reported alleviation of their symptoms, no consistent improvement has been demonstrated in lung function. Guaifenesin is reported to reduce the viscosity of tenacious sputum and is used as an expectorant for productive cough.
On the other hand, Salbutamol is a direct acting sympathomimetic agent with predominantly beta-adrenergic activity and selective action on beta2 receptors. It is used as a bronchodilator. It has more prolonged actions than isoprenaline and as a predominantly beta2 stimulant, has a bronchodilating action relatively more prominent than its effect on the heart. An additional beneficial effect of salbutamol is its action on the uterus as a relaxant, the uterine muscles as we all know contract under beta adrenergic stimulation. Thus it has gained popularity among obstetricians for controlling premature labor. However, a relative contraindication to its use is among pregnant patients with vaginal bleeding because it may cause pulmonary edema on them.

Rhinol: For the relief of bronchospasm in bronchial asthma, chronic bronchitis, emphysema and other reversible obstructive pulmonary diseases.
Rhinol Plus: Respiratory disorders complicated by bronchospasm and excessive secretion of tenacious mucus, bronchial asthma, chronic bronchitis and emphysema.

Rhinol: Syrup: Children: 2-6 years: ½-1 teaspoonful (2.5-5 mL).
6-12 years: 1 teaspoonful (5 mL).
Over 12 years: 1-2 teaspoonfuls (5-10 mL).
All doses to be taken 3-4 times a day or as prescribed by the physician.
Adult: 2 teaspoonfuls (10 mL). 3-4 times a day or as prescribed by the physician.
Rhinol Plus: Capsule: Adult: 1-2 capsules two to three times a day.
Children: 6-12 years old: 1 capsule two to three times a day or as prescribed by the physician.
Syrup: 7-12 years old: 10 mL (2 teaspoonfuls) every four hours.
2-6 years old: 5 mL (1 teaspoonful) every four hours.
Or as prescribed by the physician.

Rhinol: Should not be prescribed to patients under treatment with beta blockers. Also contra-indicated in pregnancy, to patients suffering from thyrotoxicosis and to patients hypersensitive to Salbutamol.

Rhinol: Salbutamol and nonselective β-blocking drugs e.g. propranolol, should not usually be prescribed together.
Rhinol Plus: Sympathomimetics may produce a wide range of adverse effects most of which mimic the results of excessive stimulation of the sympathomimetic nervous system. Clinically this is manifested by confusion, irritability, tremor, insomnia and restlessness. Appetite may be reduced and nausea and vomiting may occur.
Salbutamol also considered to posses mucolytic property. It is believed to act on the cilia of the respiratory tract and aside from bronchodilation can produce lysis of thick mucus.

Rhinol: Administration of drugs during pregnancy should only be considered if the excreted benefits to the mother is greater than any possible risk to the fetus. As salbutamol is probably secreted in the breast milk used by nursing mothers, it is not recommended unless the expected benefits outweigh any potential risk. It is not known whether salbutamol in breast milk has harmful effects on the neonate.

Rhinol: Salbutamol may cause a line tremor of skeletal muscle in some patients: usually the hands are most obviously affected. A few patients experience feeling of tension, this is also due to the effects on skeletal muscle and not to direct CNS stimulation. Hypersensitivity reactions, angioedema, urticaria, bronchospasm, hypertension and collapse have been reported very rarely.
Rhinol Plus: Fine tremor skeletal muscle, feeling of tension, peripheral vasodilation, a compensatory small increase in heart rate, headache, transient muscle cramps, hypersensitivity reactions, hyperacidity in children.

Store at temperatures not exceeding 30°C.

Antiasthmatic & COPD Preparations

R05CA10 - combinations ; Belongs to the class of expectorants. Used in the treatment of wet cough.
R03CC02 - salbutamol ; Belongs to the class of adrenergics for systemic use, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.

Rx