Renoguard Mechanism of Action

Pharmacology: Mechanism of Action: The mechanism of action of Ketoanalogue of essential amino acids is believed to involve in the prevention and therapy of damages due to faulty or deficient metabolism in chronic renal insufficiency.
Ketoanalogues of essential amino acids allow the intake of essential amino acids while minimizing the amino nitrogen intake.
Pharmacodynamics: Renoguard tablets are administered for nutrition therapy in chronic kidney disease.
Renoguard allows the intake of essential amino acids while minimizing amino-nitrogen intake.
Following absorption, the keto- and hydroxy-analogues are transaminated to the corresponding essential amino acids by taking nitrogen from non-essential amino acids, thereby decreasing the formation of urea by re-using the amino group. Hence, the accumulation of uraemic toxins is reduced. Keto and hydroxy acids do not induce hyperfiltration of the residual nephrons. Ketoacid containing supplements exert a positive effect on renal hyperphosphataemia and secondary hyperparathyroidism. Moreover, renal osteodystrophy may be improved. The use of Renoguard in combination with a very low protein diet allows to reduce nitrogen intake while preventing the deleterious consequences of inadequate dietary protein intake and malnutrition.
Pharmacokinetics: The plasma kinetics of amino acids and their integration in metabolic pathways are well established. It should nevertheless be noted that in uremic patients, the plasma disturbances do not seem to depend on digestive amino acid intake, and that the post-absorptive kinetics seems to be disturbed very early in the development of the disease.