Hypovolemia should be corrected prior to the administration of ketorolac trometamol.
The IV bolus must be given over no less than 15 seconds.
The IM administration should be given deeply and slowly into the muscle.
The analgesic effect begins in 30 minutes with maximum effect occurring in 1-2 hours after dosing IV or IM. The duration of analgesic effect is usually 4-6 hours.
For breakthrough pain, do not increase the dose or the frequency of ketorolac trometamol. Consideration should be given to supplementing these regiments with low doses of opioids unless otherwise contraindicated.
For the short-term management of pain, an initial IM ketorolac trometamol loading dose is recommended of 30 mg or 60 mg, and if necessary therapy is then continued with 15 mg or 30 mg administered every 6 hours.
The maximum daily dose is 120 mg, but if needed, the dose can be increased up to 150 mg in the first day of treatment. A 30 mg (IM) dose is optimal dose for relieving moderate post-operative pain. For those with severe pain, a 90 mg dose should be given. (See Table 1.)
