Patients with known hypersensitivity to ketorolac trometamol or in patients whom aspirin or other NSAIDs induce serious allergic manifestations.
Patients with acute peptic ulcer, patients with recent gastrointestinal bleeding or perforation and in patients with a history of peptic ulcer disease or gastrointestinal bleeding.
Patients with severe renal impairment or patients at high risk of renal failure.
In labor and delivery, it may adversely affect fetal circulation and inhibit uterine contractions, thus increasing the risk of uterine hemorrhage.
Nursing mother because of the potential adverse effects of prostaglandin inhibiting drugs on neonates.
Hemostasis disorders.
Patients with suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, incomplete hemostasis and those at high risk of bleeding.
Patients in concomitant use of other NSAIDs and probenecid.
Ketorolac is contraindicated for neuraxial (epidural or intrathecal) administration.
Absolute contraindication: Not to be given to those patients who have history of: Stroke, cerebrovascular accident, CVA; Heart attack, myocardial infarction, MI; Coronary artery bypass graft, CABG; Congestive heart failure (CHF) NYHA II-IV.
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