Raxide Adverse Reactions

Adverse reactions to Ranitidine are generally infrequent and are reversible following a reduction of dosage or withdrawal of therapy. The most common side effects reported have been diarrhea, dizziness, tiredness, headache and rashes. Reversible confusional states, especially in the elderly or in seriously ill patients such as those with renal failure, have occasionally occurred. Other adverse effects which have been reported rarely are hypersensitivity reactions and fever, arthralgia and myalgia, blood disorders including agranulocytosis or neutropenia and thrombocytopenia, interstitial nephritis, hepatotoxicity, and cardiovascular disorders.
Carcinogenicity: An association between H₂ receptor antagonists and gastric cancer has been proposed following individual case reports, the finding of tumors in long term high-dose animal studies, and the possibility that nitrites and nitroso compounds maybe produced; but such proposals are considered to have little clinical relevance. The excess risk of gastric cancer reported in patients taking Ranitidine decreases with time and there is no evidence for any long-term persistence of the effect.
Effects on the blood: Leucopenia, thrombocytopenia, and pancytopenia have all been reported with Ranitidine with neutropenia and agranulocytosis occurring most often.
Effects on the cardiovascular system: Bradycardia, atrioventricular block, and cardiac arrest have been reported rarely during Ranitidine therapy; a positive inotropic effect, without significant changes in heart rate or blood pressure, has also been reported in healthy subjects.
Effects on the liver: There have been some case reports of Ranitidine hepatotoxicity.
Effects on the nervous system: Ranitidine has been associated with a number of adverse neurological effects including confusion, loss of colour vision, aggressiveness, hallucinations and severe headache.
Hypersensitivity: Respiratory stridor and an urticarial rash.