Raxide

Duodenal & gastric ulcer including that associated w/ H. pylori, NSAID-associated peptic ulcer, post-op ulcer, acute reflux esophagitis, Zollinger-Ellison syndrome, chronic episodic dyspepsia, symptomatic relief in GERD, & prophylaxis of Mendelson's syndrome.

Adult (including the elderly) 150 mg bid. Duodenal & gastric ulcer 150 mg bid or 300 mg at night. Ulcers following NSAID therapy or associated w/ continued NSAIDs 8 wk treatment may be necessary. Prevention of NSAID-associated duodenal ulcers 150 mg bid may be given concomitantly w/ NSAID therapy. Higher healing rates w/ 300 mg bid for 4 wk than at those at 4 wk w/ 150 mg bid or 300 mg at night. Duodenal ulcers associated w/ H. pylori infection 300 mg at bedtime or 150 bid, may be given w/ oral amoxicillin 750 mg tid & metronidazole 500 mg tid for 2 wk. Patient who has responded to short term therapy, particularly w/ history of recurrent ulcer Maintenance treatment: Reduced dosage of 150 mg at bedtime. GERD 150 mg bid for 2 wk. Can be repeated if initial symptomatic response is inadequate. Oesophageal reflux disease 150 mg bid or 300 mg at bedtime for up to 8 wk or 12 wk if necessary. Moderate to severe oesophagitis May increase to 150 mg qid for up 12 wk. Healed oesophagitis Adult 150 mg bid for long term treatment. Zollinger-Ellison syndrome 150 mg tid & may be increased as necessary. Chronic episodic dyspepsia 150 mg bid for up to 6 wk. Prophylaxis of haemorrhage from stress ulceration in seriously ill patients or prophylaxis of recurrent haemorrhage in patients bleeding from peptic ulceration 150 mg bid, may be substituted for inj once oral feeding commences. Prophylaxis of acid aspiration (Mendelson's) syndrome 150 mg 2 hr before anaesth, & preferably 150 mg the previous evening. Obstet patient in labour 150 mg every 6 hr. Addition of a non-particulate antacid (eg, Na citrate) is recommended if general anaesth is required. Childn ≥12 yr Adult dose. Childn Peptic ulcer 4-8 mg/kg/day as 2 divided doses. Max: 300 mg/day for 4 wk. Another 4 wk of therapy, in patient w/ complete healing. GERD 5-10 mg/kg/day as 2 divided doses. Max: 600 mg (likely to apply in heavier childn or adolescent w/ severe symptoms). Renal impairment (CrCl <50 mL/min) 150 mg at night for 4-8 wk. If an ulcer has not healed after treatment, 150 mg bid should be instituted followed, if need be, by maintenance treatment of 150 mg at night.

May be taken with or without food.

Hypersensitivity.

May mask symptoms of gastric carcinoma in patients w/ gastric ulcer (eg, dyspepsia, patient of middle age over w/ new or recent changed dyspeptic symptoms). History of peptic ulcer. Avoid in patients w/ history of acute porphyria. Severe renal impairment. Pregnancy & lactation. Elderly.

Diarrhea, dizziness, tiredness, headache & rashes. Reversible confusional states, especially in the elderly or in seriously ill patients (eg, renal failure).

May reduced absorption w/ high doses of sucralfate (2 g).

Antacids, Antireflux Agents & Antiulcerants

A02BA02 - ranitidine ; Belongs to the class of H2-receptor antagonists. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Rx