Sign Out
Clinical symptoms of overdose start to appear at a dose of 10 mg. Though signs and symptoms do not appear immediately and may only occur in a delay of up to 12 hours after ingestion of drugs. The peak intensity of the syndrome may not be reached until for a day following the overdose. Death has been reported following overdose; therefore, immediate hospitalization with continuous patient observation for at least two days following ingestion is strongly recommended.
Signs and symptoms of monoamine oxidase (MAO) inhibitor overdose may include: drowsiness, faintness, dizziness, hyperactivity, agitation, irritability, severe headache, hallucinations, trismus, opisthotonos, convulsions, and coma; rapid and irregular pulse, hypertension, hypotension and vascular collapse; precordial pain, respiratory depression and failure, hyperpyrexia, diaphoresis, and cool and clammy skin.
There is no specific antidote. Treatment of overdose is symptomatic and supportive. Respiration should be supported by appropriate measures, including management of the airway, use of supplemental oxygen, and mechanical ventilatory assistance as required. Monitoring of body temperature and intensive management of hyperpyrexia may be required. Maintenance of fluid and electrolyte balance is essential. For this reason, in cases of overdose, dietary tyramine restriction should be observed for several weeks to reduce risk of hypertensive tyramine reaction.
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