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In an oral high-dose tolerability study in angina patients, the incidence of dizziness, nausea and vomiting increased in a dose-dependent manner. In addition to these adverse events, diplopia, lethargy and syncope were observed in an IV overdose study in healthy volunteers. In the event of overdose, the patient should be closely monitored and the treatment should be symptomatic and supportive.
Approximately 62% of ranolazine is bound to plasma proteins and therefore, complete clearance by hemodialysis is unlikely.
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