Quetiapro Overdosage

In clinical trials, survival has been reported in acute overdoses of up to 30 grams of quetiapine. Most patients who overdosed experience no adverse reactions or recovered fully from the reported reactions. Death has been reported in a clinical trial following an overdose of 13.6 grams of quetiapine alone.
In general, reported signs and symptoms were those resulting from an exaggeration of the drug's known pharmacological effects (i.e., drowsiness and sedation, tachycardia and hypotension). Patients who have pre-existing severe cardiovascular disease may beat an increased risk of the effects of overdose.
Management of overdose: There is no specific antidote to quetiapine. Therefore, appropriate supportive measures should be instituted. In cases of severe signs, the possibility of multiple drug involvement should be considered. In cases where hypotension and circulatory collapse occurs, it should be treated with appropriate measures such as intravenous fluids and/or sympathomimetic agents (epinephrine and dopamine should not be used). In cases of severe extrapyramidal symptoms, anticholinergic medication should be administered. Close medical supervision and monitoring should continue until patient recovers.