Adult Schizophrenia Initially 25 mg bid (day 1), 50 mg bid (day 2), 100 mg bid (day 3) & 150 mg bid (day 4). Adjust dose to 300-450 mg daily in 2 or 3 divided doses. Max: 750 mg daily.
Manic episodes associated w/ bipolar disorder Initially 50 mg bid (day 1), 100 mg bid (day 2), 150 mg bid (day 3) & 200 mg bid (day 4). Adjust dose to 400-800 mg daily. Dose increment should not be >200 mg daily.
Major depressive episodes in bipolar disorder Administer once daily at bedtime. Total daily dose for 1st 4 days: 50 mg (day 1), 100 mg (day 2), 200 mg (day 3) & 300 mg (day 4). May then be adjusted to 400 mg on day 5 up to 600 mg by day 8.
Preventing recurrence of manic, mixed or depressive episodes in bipolar disorder Patient who has responded for acute treatment of bipolar disorder should continue therapy at same dose administered at bedtime. Adjust dose depending on response w/in 300-800 mg/day. Lowest effective dose used for maintenance therapy.
Childn & adolescent 13-17 yr Schizophrenia associated w/ bipolar disorder Administer bid, may be administered tid base on response. Total daily dose for 1st 5 days: 50 mg (day 1), 100 mg (day 2), 200 mg (day 3), 300 mg (day 4) & 400 mg (day 5). Adjust dose w/in 400-800 mg/day based on response. Increments should not be >100 mg daily.
Childn & adolescent 10-17 yr Manic episodes associated w/ bipolar disorder Administer bid, may be administered tid base on response. Total daily dose for 1st 5 days: 50 mg (day 1), 100 mg (day 2), 200 mg (day 3), 300 mg (day 4) & 400 mg (day 5). Adjust dose w/in 400-800 mg/day base on response. Increments should not be >100 mg daily.
Patient w/ hepatic impairment Initially 25 mg/day. Can be increased in increments of 50 mg/day to an effective dose depending on response.
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