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Among the most serious adverse reactions pseudo-membranous colitis and toxic epidermal necrolysis occur in 1 to 10 patients in 10,000. The frequencies for pancytopenia, anaphylactic shock and Stevens-Johnson syndrome cannot be estimated from the currently available data.
In the following table, adverse reactions are listed by system organ class and MedDRA-preferred term. Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. (See Table 5.)
Click on icon to see table/diagram/imagePiperacillin therapy has been associated with an increased incidence of fever and rash in cystic fibrosis patients.
ADR in identified post marketing: Beta-lactam antibiotics, including piperacillin tazobactam, may lead to manifestation of encephalopathy and convulsions.
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