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Symptoms of orally inhaled salbutamol overdose include extensions of the common undesirable effects (e.g., seizures, hypertension or hypotension, arrhythmias, palpitations, nervousness, dizziness, fatigue, malaise, insomnia/sleeplessness, headache, tremor, dry mouth, and nausea). Angina and tachycardia have also been reported following overdosage.
Hypokalemia and metabolic acidosis may also occur following overdose with salbutamol. Serum potassium concentrations should be monitored. Lactic acidosis has been reported in association with high therapeutic doses as well as overdoses of short-acting beta-agonist therapy.
Discontinue salbutamol and institute appropriate symptomatic therapy in cases of salbutamol overdose.
Administration of a beta-adrenergic blocking agent may be appropriate but use with caution if the patient is asthmatic.
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