Provexel Drug Interactions

Sympathomimetics agents: Salbutamol should not be administered concomitantly with other short-acting sympathomimetic aerosol bronchodilators or epinephrine. If additional sympathomimetic agents are to be administered by any route, these agents should be used with caution to avoid deleterious cardiovascular effects.
Beta-adrenergic blocking agents (e.g., propranolol): Beta-adrenergic blocking agents may inhibit the effect of beta-agonists such as salbutamol. It may also produce severe bronchospasm. These drugs should be administered with caution.
Diuretics: Administration of non potassium-sparing diuretics (e.g., loop or thiazide diuretics) may result in ECG changes and/or hypokalemia and can be acutely worsened by administration of beta-agonists such as salbutamol, especially when the recommended dose of the beta-agonist is exceeded.
Digoxin: Following administration of single-dose intravenous or oral salbutamol to healthy individuals who had received digoxin for 10 days, a 16% to 22% decrease in serum digoxin concentration was observed. Although the clinical importance of these findings for patients who are receiving inhaled salbutamol and digoxin on a chronic basis is unclear, patients receiving such concomitant therapy should have their serum digoxin concentration carefully evaluated.
Monoamine oxidase inhibitors (MAOls) or Tricyclic antidepressants (TCAs): Salbutamol should be used with caution in patients receiving MAOls or TCAs or within 2 weeks of discontinuation of such agents, because the effect of salbutamol on the vascular system may be potentiated. Alternative therapy should be considered in patients taking MAOls or TCAs.