Pred 20 Adverse Reactions

Large doses of corticosteroids, or of corticotropin may produce Cushingoid symptoms typical of hyperactivity of the adrenal cortex, with moon face, hirsutism, buffalo hump, flushing, increased bruising, ecchymoses, striae, and acne; sometimes leading to a fully developed Cushing's syndrome. If administration is discontinued, these symptoms are usually reversed; but sudden cessation is dangerous.
Other adverse effects include amenorrhea, hyperhidrosis, skin thinning, ocular changes including development of cataract, mental and neurological disturbances, intracranial hypertension, acute pancreatitis, and aseptic necrosis of bone. An increase in coagulability of the blood may lead to thromboembolic complications. Peptic ulceration has also been reported. Muscle weakness and wasting occur occasionally, particularly when corticosteroids are taken in large doses. The former arises from the mineralocorticoid properties of corticosteroids, the latter from their glucocorticoid properties and is most evident with triamcinolone.