Pneumosolv Dosage/Direction for Use

Intramuscular (IM)/Intravenous (IV): Ceftriaxone is administered as the sodium salt by slow intravenous injection over 2 to 4 minutes, by intermittent intravenous infusion over at least 30 minutes, or by deep intramuscular injection. If more than 1 gram is to be injected intramuscularly then the dose should be divided between more than one site. Doses are expressed in terms of the equivalent amount of ceftriaxone.
Adults: 1 to 2 grams daily as a single dose or in two divided doses; in severe infections up to 4 grams daily may be given.
Uncomplicated gonorrhea: IM, single dose of 250 mg.
Surgical infection: Single dose of 1 gram may be administered 0.5 to 2 hours prior to surgery; a 2 gram dose is suggested before colorectal surgery.
Prevention of secondary cases of meningococcal meningitis: IM, 250 mg.
Children and Infants: 20 to 50 mg per kg body weight once daily; in severe infections up to 80 mg per kg daily may be given.
Prevention of secondary cases of meningococcal meningitis: IM, 125 mg.
Neonates: Maximum dose should not exceed 50 mg per kg; intravenous dose in neonates should be given over 60 minutes. Doses above 50 mg per kg should be administered by intravenous infusion only.
A reduction of dosage may be necessary in patients with severe renal impairment and in those with both impaired renal and hepatic function; plasma concentrations should be monitored in such patients.
Or as prescribed by the physician.
Preparation of Dosage Form: To prepare initial dilution for intramuscular use, 0.9 mL of sterile water for injection, 0.9% sodium chloride injection, 5% dextrose injection, bacteriostatic water for injection (with 0.9% benzyl alcohol), or 1% lidocaine hydrochloride injection (without epinephrine) should be added to each 250 mg vial, 1.8 mL of diluent should be added to each 500 mg vial, 3.6 mL of diluent should be added to each 1 gram vial or 7.2 mL of diluent should be added to each 2 gram vial to provide a concentration approximately 250 mg per mL. Alternatively, to reduce the volume of intramuscular injection, a solution of 350 mg per mL may be prepared by adding 1 mL of diluent to each 500 mg vial, 2.1 mL of diluent to each 1 gram vial or 4.2 mL of diluent to each 2 gram vial. The 350 mg per mL solution is bioequivalent to a 250 mg per mL solution.
To prepare initial dilution for intravenous use, 2.4 mL of appropriate diluent should be added to each 250 mg vial, 4.8 mL of diluent should be added to each 500 mg vial, 9.6 mL diluent should be added to each 1 gram vial, or 19.2 mL of diluent should be added to each 2 gram vial to provide concentration of approximately 100 mg per mL. The reconstituted solution may be further diluted to 50 or 100 mL with an appropriate diluent for intravenous infusion.