Stability: After reconstitution for intramuscular use, solutions retain at least 90% of their potency for 1 to 3 days at room temperature or for 3 to 10 days if refrigerated at 4°C, depending on concentration and diluent. After reconstitution for intravenous use, solutions retain at least 90% of their potency for 3 days at room temperature or for 10 days if refrigerated at 4°C, when stored in glass or polyvinyl chloride (PVC) containers in suitable diluents.
After reconstitution for intravenous use with 5% dextrose injection or 0.9% sodium chloride injection, solutions at concentrations of 10-40 mg per mL retain their potency for 26 weeks at 20°C when stored in PVC or polyolefin containers. Frozen solutions should be thawed at room temperature. Once thawed, solutions should not be refrozen.
Solutions may vary in color from light yellow to amber, depending on length of time in storage, concentration and diluent.
Incompatibilities: The admixture of Ceftriaxone with other medications, including pentamidine isethionate, or with labetatol hydrochloride is not recommended.
The admixture of beta-lactam antibacterials (penicillins and cephalosporins) and aminoglycosides may result in substantial mutual inactivation. If they are administered concurrently, they should be administered in separate sites. Do not mix them in the same intravenous bag or bottle.
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