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Hypersensitivity to pioglitazone HCl or to any of the components of Piozone; patients with established New York Heart Association (NYHA) Class III or or IV heart failure; serious hepatic impairment; type 1 diabetes or diabetic ketoacidosis.
Use in pregnancy: Pregnancy Category C. Oral hypoglycemic agents (including pioglitazone) are not recommended during pregnancy. Although there are no adequate and well-controlled studies of pioglitazone in pregnant women, animal studies show increased rates of post-implantation loss, delayed development, reduced fetal weights, and delayed parturition at doses 10-40 times the maximum recommended human dose. Maintaining blood glucose levels as close to normal as possible is necessary during pregnancy since abnormal blood glucose levels are associated with a higher incidence of congenital abnormalities. Insulin is recommended during pregnancy.
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