Piozone Adverse Reactions

Respiratory Effects: Upper respiratory tract infection, dyspnea, sinusitis, bronchitis, pulmonary edema, and pharyngitis.
Endocrine Effects: Aggravated diabetes mellitus, erectile dysfunction.
Dose-related mild to moderate hypoglycemia has been reported when pioglitazone was used in combination with either a sulfonylurea or insulin.
Cardiovascular Effects: Congestive heart failure and edema/peripheral edema have been reported especially when pioglitazone is used in combination with insulin.
Cardiac failure, heart failure, chest pain, abnormal electrocardiogram (ECG), hypertension, ischemia, angina pectoris, myocardial infarction, myocardial ischemia and transient ischemic attacks. Heart rate and rhythm disorders have also been reported.
Central Nervous System Effects: Headache, hypoesthesia, vertigo, dizziness, and insomnia.
Musculoskeletal Effects: Arthralgia, myalgia, back pain, and cramps (legs). Increased risk of fractures in female patients taking pioglitazone has been reported (see Warnings and Precautions).
Hepatic Effects: Fatal and nonfatal hepatic failure and hepatitis have been reported. During all clinical trials in the US, 11 of 2561 (0.43%) patients treated with pioglitazone had ALT values ≥3 ULN. All patients with follow-up values had reversible elevations in ALT. In the population of patients treated with pioglitazone, mean values for bilirubin, AST, ALT, alkaline phosphatase, and gamma-glutamyl transferase (GGT) were decreased at the final visit compared with baseline. Sporadic, transient elevations in creatine phosphokinase (CPK) levels have also occurred.
Hematologic Effects: Anemia has been reported in patients taking pioglitazone in combination with sulfonylureas, metformin or insulin.
Dose-related decreases in hemoglobin and hematocrit have been associated with pioglitazone use.
Renal Effects: Urinary tract infection, hematuria, glycosuria, and proteinuria.
Gastrointestinal Effects: Flatulence, increased appetite and diarrhea.
Eye Disorders: New onset or worsening diabetic macular edema with decreased visual acuity has been reported.
Tumors: Urinary bladder tumors (rare).
Others: Tooth disorder, accidental injury, fatigue, sweating, pain in extremity, weight gain, increased lactic dehydrogenase levels.