Cautions is recommended when giving olanzapine by mouth to such patients and to those with cerebrovascular disease or conditions predisposing to hypotension. It is recommended that blood pressure is periodically assessed in elderly patients.
Cautions is also advised in those with conditions such as benign prostatic hyperplasia or paralytic ileus.
Olanzapine is not recommended in Parkinson's disease since its use has commonly been associated with an increase in parkinsonian symptoms and hallucinations. It should be used with caution in patients with hepatic impairment, or a history of blood dyscrasias, bone marrow depression, or myeloproliferative disease. Seizures are rare with olanzapine but it should be use with care in those with a history of seizures or with conditions that lower the seizure threshold.
Olanzapine does not affect the performance of skilled tasks such as driving.
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