Olazin Mechanism of Action

Pharmacology: Pharmacokinetics: Olanzapine is well absorbed from the gastrointestinal tract after oral doses but undergoes considerably first-pass metabolism. Peak plasma concentrations are achieved about 5 to 8 hours after oral dose and about 15 to 45 minutes after an intramuscular dose. Olanzapine is about 93% bound to plasma proteins. It is extensive metabolised in the liver, primarily by direct glucuronidation and by oxidation mediated through the cytochrome P450 isoenzymes CYP1A2, and a fewer extent, CYP2D6. The 2 major metabolites, 10-N-glucuronide and 4-N-desmethyl olanzapine appears to be inactive. About 57% of a dose is excreted in the urine mainly as metabolites, and about 30% appears in the faeces. The mean plasma elimination half-life has been variously reported to be about 30 to 38 hours half-life tends to be longer in female than in male patients. Olanzapine is distributed into breast milk.