Noxadium 4000/Noxadium 6000

Acute DVT & ST-segment elevation MI. Prophylaxis of DVT & ischaemic complications of unstable angina & non-Q-wave MI.

SC Abdominal surgery 40 mg once daily w/ initial dose given 2 hr prior to surgery. Usual duration: 7-10 days. Hip or knee replacement surgery 30 mg every 12 hr w/ initial dose given 12-24 hr after surgery. Hip replacement surgery 40 mg once daily w/ initial dose given 12 hr prior to surgery may be considered. Initial phase of thromboprophylaxis in hip replacement surgery patient Continue prophylaxis w/ 40 mg once daily for 3 wk. Usual duration: 7-10 days. Medical patient at risk for thromboembolic complication due to severely restricted mobility during acute illness 40 mg once daily. Usual duration: 6-11 days.

Hypersensitivity. Active major bleeding, thrombocytopenia associated w/ +ve in vitro test for anti-platelet Ab in presence of enoxaparin Na.

Not to be administered by IM inj. Do not mix w/ other inj for infusion. Patients w/ bleeding diathesis, uncontrolled arterial HTN or history of recent GI ulceration, diabetic retinopathy, & hemorrhage. Initiate appropriate therapy if thromboembolic events occur despite prophylaxis. Discontinue agents which may enhance risk of hemorrhage prior to initiation of therapy. Use w/ extreme caution in patients w/ history of heparin-induced thrombocytopenia; conditions w/ increased risk of hemorrhage eg, bacterial endocarditis, congenital or acquired bleeding disorders, active ulcerative & angiodysplastic GI disease, hemorrhagic stroke, or shortly after brain, spinal, or ophthalmological surgery, or in patients treated concomitantly w/ platelet inhibitors. Major hemorrhages including retroperitoneal & intracranial bleeding; bleeding can occur at any site during therapy. Observe low-wt patients carefully for signs & symptoms of bleeding. Use during pregnancy only if clearly needed. Elderly who may show delayed elimination of enoxaparin.

Mild to moderate thrombocytopenia. Mild local irritation, pain, hematoma, ecchymosis, & erythema.

Enhanced risk of hemorrhage w/ anticoagulants, platelet inhibitors including ASA, salicylates, NSAIDs (including ketorolac, tromethamine), dipyridamole, or sulfinpyrazone. Co-administration w/ heparin. Cases of epidural or spinal hematomas w/ spinal/epidural anesth or spinal puncture resulting in long-term or permanent paralysis; higher risk w/ use of post-op in dwelling epidural catheters or by concomitant use of additional drugs affecting homeostasis eg, NSAIDs. Increased exposure w/ Na (prophylactic dosage & non-wt adjusted) in low-wt patients (<57 kg).

Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)

B01AB05 - enoxaparin ; Belongs to the class of heparin group. Used in the treatment of thrombosis.

Rx