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Starting Dose: 1 cap twice daily; provided this is tolerable vis-a-vis renal function. Patients previously on gabapentin will have a wash-out period of 1 week prior to start of dosing with pregabalin.
Special populations: Renal impairment and haemodialysis: Pregabalin clearance is nearly proportional to creatinine clearance (CrCl). Dosage reduction in patients with renal dysfunction is necessary. Pregabalin is effectively removed from plasma by haemodialysis. Following a 4-hour haemodialysis treatment, plasma pregabalin concentrations are reduced by approximately 50%. For patients on haemodialysis, dosing must be modified.
Paediatric Pharmacokinetics: Pharmacokinetics of pregabalin has not been adequately studied in paediatric patients.
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