Nervagest Plus Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Pregabalin 75 mg, methylcobalamin 750 mcg

Indications/Uses

Management of neuropathic pain associated w/ peripheral neuropathy; neuralgia; fibromyalgia. Adjunct therapy for adult patient w/ partial onset seizures.

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Dosage/Direction for Use

Initially 1 cap bid. Patient previously on gabapentin should have wash-out period of 1 wk prior to initiation of pregabalin.

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Overdosage

View Nervagest Plus overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity.

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Special Precautions

Discontinue immediately if swelling of the face, mouth (tongue, lips, & gums), & neck (throat & larynx); if myopathy is diagnosed or suspected or if markedly elevated creatinine kinase levels occur. Should not be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. W/drawal symptoms. Suicidal behaviour & ideation; peripheral edema; encephalopathy. Wt gain; blurred vision; decreased platelet count; PR interval prolongation may occur. Patients w/ CHF NYHA class III or IV; history of drug abuse. Concomitant use w/ drugs potential to produce constipation eg, opioid analgesics. May cause dizziness & somnolence & impair ability to drive or operate machinery. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Pregabalin: Dizziness, somnolence, headache, ataxia, asthenia, dry mouth, constipation, edema, blurred vision, wt gain, & difficulty w/ concentration/attention).

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Drug Interactions

Reduced absorption of vit B₁₂ from the GIT w/ neomycin, aminosalicylic acid, histamine H₂-antagonists, omeprazole & colchicine. Serum conc may be decreased w/ OCs. Parenteral chloramphenicol may attenuate the effect of vit B₁₂ in anemia. May experience additive CNS side effects w/ opiates or benzodiazepines. May potentiate impairment of motor skills & sedating effects of alcohol. Methylcobalamin: May alter intestinal microflora & decrease the absorption of w/ antibiotics; metformin, para-aminosalicyclic acid & KCl. May decrease enterohepatic re-absorption w/ cholestyramine, colchicine or colestipol. Produce functional deficiency w/ nitrous oxide.

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Storage

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Description

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Action

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MIMS Class

Anticonvulsants / Vitamin B-Complex / with C

ATC Classification

N02BF02 - pregabalin ; Belongs to the class of gabapentinoids. Used to relieve pain and other conditions.

Regulatory Classification

Presentation/Packing

Form

Nervagest Plus cap

Packing/Price

30's (P990/box)

Nervagest Plus

Manufacturer:

Bafna Pharma

Distributor:

Natrapharm