Neo-Pyrazon Adverse Reactions

The most frequently reported adverse effects (1 to 10%) are abdominal pain, abnormal renal function, anemia, constipation, decreased appetite, diarrhea, dizziness, dyspepsia, edema, elevated liver enzymes, flatulence, GI ulcers (gastric/duodenal), gross bleeding/perforation, headache, heartburn, increased bleeding time, nausea, pruritus, rashes, tinnitus, vertigo, and vomiting.
Less common adverse effects (<1% of patients) include: Blood and Lymphatic System: Agranulocytosis, aplastic anemia, bruising in the extremities and abdomen, eosinophilia, hematoma formation, hemolytic anemia, inhibit platelet aggregation, leukopenia, lymphadenopathy, pancytopenia, prolong bleeding time, purpura, rectal bleeding, spontaneous bleeding, stomatitis, thrombocytopenia.
Immune System: Anaphylaxis and anaphylactoid reactions (including hypotension and shock), angioedema (including facial edema), asthma, bronchospasm, chest tightness, dyspnea, eosinophilic pneumonitis, hypersensitivity, laryngeal edema, potentially severe hypotension, swelling of the eyelids, tongue, lips, pharynx or larynx, urticaria, wheezing.
Metabolism and Nutrition: Anorexia, appetite changes, hyperglycemia, hyponatremia, weight changes.
Psychiatric: Anxiety, confusion, depression, disorientation, drowsiness, hallucinations, insomnia, irritability, nervousness, nightmare, psychotic disorder.
Nervous System: Aseptic meningitis, cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage), coma, convulsions, dream abnormalities, dysgeusia impaired concentration, memory impairment, meningitis, migraine, myoclonus, paresthesia, tingling sensation, tremors.
Eye: Conjunctivitis, optic neuritis, visual impairment (blurred vision, diplopia).
Cardiovascular: Angina, arrhythmia, chest pain, circulatory shock or distress, congestive heart failure, hypertension, hypotension, myocardial infarction, palpitations, syncope, tachycardia, thrombophlebitis, vasculitis.
Respiratory, Thoracic and Mediastinal: Asthma, bronchitis, dyspnea, pharyngitis, pneumonia, pneumonitis, respiratory depression.
Gastrointestinal (GI): Coated tongue, colitis, diaphragm-like intestinal strictures, dry mouth, eructation, esophageal lesions, esophagitis, exacerbation of colitis and Crohn's disease, gastric or peptic ulcers, gastritis, GI hemorrhage, glossitis, hematemesis, hemorrhagic diarrhea, melena, pancreatitis, perforation or GI bleeding, stomatitis.
Hepatic: Abnormal liver function, cholestasis, hepatitis (including asymptomatic, acute, chronic, and fulminant), hepatocellular necrosis, jaundice, liver failure.
Skin and Subcutaneous Tissue: Alopecia, angioedema, bullous eruptions, ecchymosis, eczema, erythema multiforme, erythema, exfoliative dermatitis, Henoch-Schonlein purpura, increased sweating, photosensitivity, purpura, SJS, TEN or Lyell's syndrome, urticaria.
Renal and Urinary: Cystitis, dysuria, hematuria, increased blood urea nitrogen and serum creatinine concentrations, nephrotic syndrome, oliguria/polyuria, papillary necrosis, proteinuria, renal calculi, renal failure, tubulointerstitial nephritis, urinary tract infection.
General Disorders and Administration Site Conditions: Asthenia, malaise, tiredness.
Others: Back, leg or joint pain, death, fever, hearing impairment, impotence, infection, sepsis.