Nanoxel Description

Each vial contains paclitaxel 100 mg and 5 mL of dehydrated alcohol added until sufficient as active ingredients. It also contains polymer PNP 50 mg, sodium deoxycholate 33.35 mg, sodium citrate 50 mg and 5 mL of water for injection added until sufficient, as inactive ingredients.
Paclitaxel is a natural product with antitumor activity. Paclitaxel is obtained via a semi-synthetic process from Taxus baccata. The chemical name for paclitaxel is 5β,20-Epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine.
Paclitaxel is a white to off-white crystalline powder with the empirical formula C₄₇H₅₁NO₁₄ and a molecular weight of 853.9. It is highly lipophilic, insoluble in water and melts at around 216-217°C.
Nanoxel nanoparticle injection is a cremophor-free, clear, colorless solution, water soluble, nanoparticle formulation of paclitaxel based on polymeric carrier for drug delivery. The polymer being an amphiphilic molecule eg, having both hydrophilic and hydrophobic groups, forms nano-size micelles when exposed to an aqueous environment. Core region of the micelles consists of hydrophobic groups that serve as a reservoir where paclitaxel, a highly hydrophobic drug, is entrapped by physical incorporation and is thus shielded from the aqueous environment. The mean particle size of nanoparticles is approximately 80 nanometers.