Nanoxel Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Paclitaxel (nanoparticle inj)

Indications/Uses

Treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse w/in 6 mth of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated.

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Dosage/Direction for Use

220 mg/m² IV over 1 hr 3 wkly.

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Overdosage

View Nanoxel overdosage for action to be taken in the event of an overdose.

Contraindications

Should not be used in solid tumor ovary, breast & NSCLC patients w/ baseline neutrophil count of <1500 cells/mm³ or in patients w/ AIDS-related Kaposi's sarcoma w/ baseline neutrophil count of <1000 cells/mm³. Pregnancy & lactation.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Nanoxel detailed prescribing information

Special Precautions

Perform blood counts frequently in order to monitor the occurrence of bone marrow suppression, primarily neutropenia. Monitor infusion site for possible infiltration during therapy. Hepatic & renal impairment. Childn.

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Use In Pregnancy & Lactation

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Adverse Reactions

Neutropenia, febrile neutropenia, leukopenia, thrombocytopenia, anemia, palpitation, tachycardia, hypotension, HTN, cough, dyspnea, neuropathy, body pain, myalgia, nausea, vomiting, diarrhea, oral mucositis, rash, pruritus; bilirubin, SGOT/SGPT & alkaline phosphatase elevation; inj site reaction.

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Drug Interactions

Cytochrome P450 isoenzymes CYP2C8 & CYP3A4 substrates or inhibitors.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Nanoxel detailed prescribing information

Storage

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Description

View Nanoxel description for details of the chemical structure and excipients (inactive components).

Action

View Nanoxel mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Cytotoxic Chemotherapy

ATC Classification

L01CD01 - paclitaxel ; Belongs to the class of taxanes from plant alkaloids and other natural products. Used in the treatment of cancer.

Regulatory Classification

Presentation/Packing

Form

Nanoxel inj 20 mg/mL

Packing/Price

(vial) 1.5 mL x 1's;15 mL x 1's;5 mL x 1's

Nanoxel

paclitaxel

Manufacturer:

Fresenius Kabi

Distributor:

Zuellig