Non-steroidal anti-inflammatory drugs (NSAIDs) may antagonize the antihypertensive effect. Concurrent use with sympathomimetics may reduce the antihypertensive effect. Potassium-sparing diuretics may lead to elevation of serum potassium. Concurrent administration of sublingual nitroglycerin, long-acting nitrates, beta-blockers or other antianginal agents with Amlodipine may produce additive antihypertensive and anti-anginal effects.