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Symptoms: The effects of overdosage are expected to be primarily related to salbutamol because acute overdosage with ipratropium bromide is unlikely as it is not well absorbed systematically after inhalation or oral administration. Hypokalemia may occur following overdosage. Serum potassium levels should be monitored. Manifestations of overdosage with salbutamol may include angina pain, hypertension, hypokalemia and tachycardia.
Treatment: The preferred antidote for overdosage with salbutamol is a cardioselective β-blocking agent but due care and attention should be taken while administering these drugs in patients with a history of bronchospasm.
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