The combination has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines and steroids, commonly used in the treatment of asthma and COPD, without adverse reactions. Caution is advised when salbutamol sulfate and ipratropium bromide is co-administered with other anticholinergic drugs, β-blockers, α-adrenergic agents, diuretics, monoamine oxidase inhibitors or tricyclic antidepressants.