Mucopid Mechanism of Action

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Full Prescribing Info

Action

Pharmacology: Pharmacodynamics: Rebamipide prevents mucosal erosion and damage. The drug augments gastric blood flow, reduce free oxygen radicals mediated oxidative stress and lipid per oxidation and promote prostaglandin biosynthesis in the duodenal wall.
Pharmacokinetics: The effective concentration of Rebamipide is in the range of 1-1000 μm. The following table briefly explains the pharmacokinetic parameter of Rebamipide. (See table.)

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Up to 98.4% of ingested Rebamipide is bound to plasma proteins. It is metabolized in the liver by human cytochrome P450 enzyme. The cytochrome P450 enzyme acts on Rebamipide through hydroxylation and glucuronidation, resulting in the formation of 6-hydroxy and 8-hydroxyrebamipide. The role of glucuronidation in the metabolism of rebamipide is very low and nonsignificant. Drug interactions of Rebamipide with other drugs is very low and safely used concomitantly with other drugs.

rebamipide

Manufacturer:

BCWorld Pharm

Distributor:

RiteMED