Monowel Indications/Uses

TREATMENT: Cefoxitin sodium (Monowel) is indicated for the treatment of the following infections due to susceptible organisms: Peritonitis and other intra-abdominal and intrapelvic infections; Gynecological infections; Septicemia; Endocarditis; Urinary tract infection, including uncomplicated gonorrhea; Respiratory tract infections; Bone and joint infections; Skin and soft tissue infections.
Cefoxitin sodium (Monowel) is a broad-spectrum bactericidal antibiotic indicated for the treatment of infections caused by susceptible strains of gram-positive and gram-negative pathogens both aerobic and anaerobic. Cefoxitin sodium (Monowel) has been clinically effective not only in infections due to antibiotic sensitive organisms, but also in infections due to organisms resistant to one or more of the following antibacterial agents: penicillin, ampicillin, carbenicillin, tetracyclines, erythromycin, chloramphenicol, other cephalosporins, kanamycin, gentamycin, tobramycin and sulfamethoxazole-trimethoprim. Many gram-negative pathogens are resistant to penicillins and cephalosporin through the action of the beta-lactamases which are produced by these pathogens. Cefoxitin sodium (Monowel) is remarkably stable in the presence of these bacterial beta-lactamases, both penicillinases and cephalosporinases. Hence, the clinical efficacy of Cefoxitin sodium (Monowel) extends to many infections caused by such pathogens, of which the following are of particular clinical importance: E. coli; Klebsiella; Proteus mirabilis; Proteus, indole positive (which include the organisms now called Morganella morganii and Proteus vulgaris); Serratia marcescens; Providencia (including Providencia rettgeri) and the anaerobic Bacteroides fragilis. Cefoxitin sodium (Monowel) is indicated for the treatment of mixed infections caused by susceptible strains of aerobic and anaerobic bacteria. The majority of these mixed infections are associated with contamination by fecal flora as well as flora originating from the vagina, skin and mouth. In these mixed infections, Bacteroides fragilis is the most commonly encountered anaerobic pathogen and is usually resistant to aminoglycosides, cephalosporins, and virtually all penicillins. However, Bacteroides fragilis is usually susceptible to Cefoxitin sodium (Monowel). Cefoxitin sodium (Monowel) is indicated for adjunctive therapy in the surgical treatment of infections, including abscesses, infection complicating hollow viscous perforations, cutaneous infections and infections of serous surfaces, whether caused by aerobes, mixed aerobes and anaerobes, or anaerobes.
PROPHYLAXIS: Cefoxitin sodium (Monowel) is indicated for the prevention of certain post-operative infections in patients undergoing surgical procedures that are classified as contaminated, potentially contaminated, or where the occurrence of postoperative infection could be especially serious.