Monowel Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Warnings Special Precautions Adverse Reactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cefoxitin Na

Indications/Uses

Peritonitis & other intra-abdominal & intrapelvic infections; septicemia; endocarditis; gynecological, resp tract, bone & joint, skin & soft tissue infections; UTI, including uncomplicated gonorrhea. Infections caused by susceptible strains of gm +ve & gm-ve pathogens both aerobic & anaerobic. Adjunctive therapy in the surgical treatment of infections, including abscesses, infection complicating hollow viscous perforations, cutaneous infections & infections of serous surfaces whether caused by aerobes, anaerobes; mixed aerobes or anaerobes. Prophylaxis to post-op infections.

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Dosage/Direction for Use

Adult 1-2 g 8 hrly. Uncomplicated infection 1 g every 6 or 8 hr. Total daily dosage: 3-4 g. Moderately severe or severe infection 2 g every 6 or 8 hr. Total daily dosage: 6-8 g. Infections generally needing antibiotics in higher doses 2-3 g every 4 or 6 hr. Total daily dosage: 12 g. Renal insufficiency Initially 1-2 g as loading dose. Patient undergoing hemodialysis 1-2 g as loading dose after each hemodialysis. Mild impairment (CrCl 30-50 mL/min) 1-2 g every 8-12 hr. Moderate impairment (CrCl 10-29 mL/min) 1-2 g every 12-24 hr. Severe impairment (CrCl 9-5 mL/min) 0.5-1 g every 12-24 hr. Essentially no renal function (CrCl <5 mL/min) 0.5-1 g every 24-48 hr. Uncomplicated UTI 1 g IM bid. Uncomplicated gonorrhea 2 g IM given w/ 1 g of probenecid PO at the same time or up to 1 hr before. Neonate, infant & childn 20-40 mg/kg 6-12 hrly, may be increased to 200 mg/kg. Max: 12 g/day. Prophylactic use in general surgery Adult 2 g IM or IV ½-1 hr before initial incision, then 2 g 6 hrly. Neonate, infant & childn 30-40 mg/kg. Caesarean section 2 g IV. Prophylaxis in gynecologic surgical procedure 2 g IM or IV 1 to 1½ hr prior to surgery. Prolonged or heavily contaminated procedures Additional 2 g at 6 hr interval.

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Contraindications

Hypersensitivity to cephalosporins.

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Warnings

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Special Precautions

Renal insufficiency. Pregnancy & lactation. Neonates (for soln containing preservatives).

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Adverse Reactions

Phlebitis, inflammation at the inj site, GI reactions eg, nausea & vomiting.

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Caution For Usage

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Storage

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Description

View Monowel description for details of the chemical structure and excipients (inactive components).

Action

View Monowel mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Cephalosporins

ATC Classification

J01DC01 - cefoxitin ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Monowel powd for inj 1 g

Packing/Price

1's (P846.72/vial)

Monowel

cefoxitin

Manufacturer:

Biolab

Distributor:

Cathay Drug