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Licensed product information recommends caution when potent inducers of the cytochrome P450 isoenzyme CYP3A4 such as phenytoin, phenobarbital, or rifampicin are given with Montelukast.
On Corticosteroids, with reports of peripheral oedema in patients given Montelukast and prednisone.
With Phenobarbital, peak serum concentrations after a single dose of Montelukast 10 mg were reduced by 20% in 14 healthy subjects who took phenobarbital 100 mg daily for 14 days, and area under the serum concentration-time curve was reduced by 38%. However, it was not thought that montelukast doses would need adjustment if given with phenobarbital.
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