Metromic/Metromic Forte Use In Pregnancy & Lactation

General advice: Pregnancy category is C.
Women of childbearing potential/birth control (contraception): Since the effects of active ingredients in metronidazole and miconazole nitrate suppositories for fetus and newborn growth are not clearly known, women who must use this product should avoid pregnancy with a proper birth control method.
Pregnancy: Preclinical studies on animals regarding the pregnancy, embryonal/fetal growth, perinatal and/or postnatal growth are insufficient. Potential risk for human is not known.
There is insufficient data regarding the use of metronidazole and miconazole nitrate suppositories in the first trimester of pregnancy. Therefore, Metronidazole + Miconazole (Metromic) 500 mg/100 mg and Metronidazole + Miconazole (Metromic Forte) 750 mg/200 mg Vaginal Suppositories should not be used in the first trimester of pregnancy. In the second and third trimesters, benefit/risk ratio should be evaluated by a physician, should not be used unless it is necessary.
Lactation: Breastfeeding should be discontinued, since metronidazole appears in milk. Breastfeeding can be started again 24-48 hours after the end of treatment.
Reproduction/fertility: There is no evidence regarding hazardous effect on human and animal fertility when metronidazole or miconazole nitrate is administered alone.