No data is available on metronidazole overdose when administered via intravaginal route. When introduced into the vagina metronidazole can be absorbed in sufficient quantities to have systemic effects.
When excessive amount of suppositories is applied, systemic effects may occur due to metronidazole, but intravaginal metronidazole is not expected to cause life-threatening symptoms.
Symptomatic and supportive treatment should be instituted. There is no specific antidote for metronidazole. Cure can be provided in individuals who ingested a dose of 12 g of metronidazole.
Symptoms of metronidazole overdose are nausea, vomiting, abdominal pain, diarrhea, itching, metallic taste, ataxia, dizziness, paresthesia, convulsion, leucopenia, darkening of urine; symptoms of miconazole nitrate overdose are sore mouth and throat, anorexia, nausea, vomiting, headache, diarrhea.
In case of accidental ingestion of large amounts of suppositories into the gastrointestinal tract, perform a corresponding lavage technique if necessary.
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