Metoclosil Indications/Uses

Metoclopramide hydrochloride is a substituted benzamine used for its prokinetic and antiemetic properties. It stimulates the motility of the upper gastrointestinal tract without affecting gastric, biliary, or pancreatic secretion and increases gastric peristalsis, leading to accelerated gastric emptying. Duodenal peristalsis is also increased which decreases intestinal transit time. The resting tone of the gastro-esophageal sphincter is increased and the pyloric sphincter is relaxed. Metoclopramide possesses Parasympathomimetic activity as well as being a dopamine-receptor antagonist with a direct effect on the chemoreceptor trigger zone. It may have serotonin-receptor (5-HT₃) antagonist properties.
Metoclopramide is used in disorders of decreased gastrointestinal motility such as gastroparesis or ileus; in gastro-esophageal reflux disease and dyspepsia; and in nausea and vomiting associated with various gastrointestinal disorders, with migraine, following surgery, and with cancer therapy. Metoclopramide is of no value in the prevention or treatment of motion sickness. It may be used to stimulate gastric emptying during radiographic examinations, to facilitate intubation of the small bowel, and in the management of aspiration syndromes.