Omeprazole may be given orally before meals. Omeprazole capsule must be swallowed whole with water and should not be opened, crushed or chewed.
Peptic Ulcer: Omeprazole 20 mg once a day. For severe cases, Omeprazole 40 mg is recommended. Healing usually occurs within 4 weeks for patients with duodenal ulcer and 8 weeks for those with gastric ulcer.
Omeprazole 10 mg to 20 mg once daily may be given for maintenance.
Duodenal Ulcer: Omeprazole 20 mg once a day for 4 to 8 weeks. The healing occurs within 4 weeks in most patients. It may require an additional 4 weeks of therapy for some patients.
Duodenal Ulcer associated with H. pylori: Triple therapy: Omeprazole 20 mg plus clarithromycin 500 mg plus amoxicillin 1000 mg each given twice a day for 10 days. If an ulcer is present at the initiation of therapy, continue Omeprazole 20 mg for an additional 18 days.
Omeprazole 20 mg plus clarithromycin 250 mg plus metronidazole 500 mg or (linidazole 500 mg) each given twice a day for one week or
Omeprazole 20 mg capsules once a day plus amoxicillin 500 mg plus metronidazole 500 mg both given three times a day for one week.
Dual Therapy: Omeprazole 40 mg once a day plus clarithromycin 500 mg three times a day for 14 days. If an ulcer is present at the initiation of therapy, continue Omeprazole 20 mg for an additional 14 days.
Omeprazole 40 mg once a day plus amoxicillin 750 mg twice a day, given for 2 weeks.
Gastric Ulcer: Omeprazole 20 mg once a day for 4 weeks. For patients with poorly responsive gastric ulcer, Omeprazole 40 mg once a day for 8 weeks.
Gastro-Esophageal Reflux Disease (GERD): Omeprazole 20 mg 1 to 2 capsules once a day, given 4 to 12 weeks.
Dyspepsia: Omeprazole 10 mg once a day could be considered as a starting or initial dose because patients may respond adequately to this dose. For patients with epigastric pain or discomfort with or without heartburn, Omeprazole 20 mg once a day is the recommended dosage for 4 weeks. If after 4 weeks of treatment with Omeprazole 20 mg once a day has not been achieved, it is recommended for further investigation.
Impaired Hepatic Function: Some recommend that the maximum daily dose for patients with impaired hepatic function is reduced to 20 mg Omeprazole 10-20 mg once a day may be sufficient for patients with impaired hepatic function. For the elderly dose adjustment is not needed.
Patients with impaired renal function dose adjustment is needed.
Or as prescribed by a physician.
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