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(Usual or as prescribed by the physician).
Omeprazole is given by mouth as capsule containing enteric-coated pellets which should be swallowed whole and not crushed or chewed.
Relief of acid-related dyspepsia: 10 mg or 20 mg daily for 2-4 weeks.
Treatment of gastro-oesophageal reflux disease: 20 mg once daily for 4 weeks.
Refractory oesophagitis: 40 mg daily; maintenance therapy is 20 mg once daily and for acid reflux is 10 mg daily.
Peptic ulcer disease: 20 mg once daily or 40 mg once daily for severe cases. Treatment is continued for 4 weeks for duodenal ulcer and 8 weeks for gastric ulcer. A dose of 10 mg to 20 mg once daily may be given for maintenance.
Treatment of NSAID-associated ulceration: 20 mg once daily.
Prophylaxis in patients with a previous history of gastroduodenal lesions who require continued NSAID treatment: 20 mg daily.
Zollinger-Ellison syndrome: Initial dose is 60 mg once daily; majority of patients are effectively controlled by doses between 20 mg-120 mg daily. Daily doses above 80 mg should be administered in divided doses.
Prophylaxis of acid aspiration during general anesthesia: 40 mg the evening before surgery and a further 40 mg 2-6 hours before the procedure.
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